Fgf21^tm1Emf
Targeted Allele Detail

Summary

• Symbol: Fgf21^tm1Emf
• Name: fibroblast growth factor 21; targeted mutation 1, Eleftheria Maratos-Flier
• MGI ID: MGI:4436716
• Gene: Fgf21 Location: Chr7:45263314-45264914 bp, - strand Genetic Position: Chr7, 29.38 cM, cytoband B2
• Alliance: Fgf21^tm1Emf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157309
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1, all of exon 2 and the 5' region of exon 3 were replaced by a neomycin cassette by homologous recombination. Quantitative PCR confirmed the absence of product in the liver, perigonadal white adipose tissue and brown adipose tissue of ketogenetic diet fed homozygous mice . (J:157309)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf21 Mutation: 22 strains or lines available

References

• Original: J:157309 Badman MK, et al., Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology. 2009 Nov;150(11):4931-40
• All: 12 reference(s)