Nfil3^tm1Pbro
Targeted Allele Detail

Summary

• Symbol: Nfil3^tm1Pbro
• Name: nuclear factor, interleukin 3, regulated; targeted mutation 1, Paul B Rothman
• MGI ID: MGI:4436769
• Gene: Nfil3 Location: Chr13:53121245-53135109 bp, - strand Genetic Position: Chr13, 27.68 cM
• Alliance: Nfil3^tm1Pbro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156521
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on IL-4-stimulated splenocytes. (J:156521)

Generation of the Nfil3^tm1Pbro allele

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfil3 Mutation: 32 strains or lines available

References

• Original: J:156521 Kashiwada M, et al., IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):821-6
• All: 15 reference(s)