Rnf19b^tm1Jkorn
Targeted Allele Detail

Summary

• Symbol: Rnf19b^tm1Jkorn
• Name: ring finger protein 19B; targeted mutation 1, Jacki Kornbluth
• MGI ID: MGI:4436863
• Synonyms: NKLAM KO
• Gene: Rnf19b Location: Chr4:128951871-128978319 bp, + strand Genetic Position: Chr4, 62.76 cM, cytoband D2.3
• Alliance: Rnf19b^tm1Jkorn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 were replaced with a neo cassette by homologous recombination. RT-PCR confirmed the absence of mRNA in IL-2-stimulated spleen cells. (J:157393)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Rnf19b^tm1Jkorn/Rnf19b^tm1Jkorn	B6.129S-Rnf19b^tm1Jkorn

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
impaired natural killer cell mediated cytotoxicity	√
immune system	√
impaired natural killer cell mediated cytotoxicity	√
decreased interferon-gamma secretion	√
neoplasm	√
increased metastatic potential	√
increased tumor growth/size	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf19b Mutation: 20 strains or lines available

References

• Original: J:157393 Hoover RG, et al., Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice. J Immunol. 2009 Dec 1;183(11):6913-21
• All: 4 reference(s)