Is(14)2Rdf
Targeted Allele Detail

Summary

• Symbol: Is(14)2Rdf
• Name: insertion, Chr 14, Riccardo Dalla-Favera 2
• MGI ID: MGI:4437013
• Gene: Is(14)2Rdf Location: unknown Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP and FRT sites as well as a PGK promoter and Hygro cassette were place about 5 kb telomeric to the alternative exon 1 of Dleu2 by homologous recombination. The targeting was done in ES cells carrying Is(14)1Rdf. The two constructs are in cis configuration. (J:156946)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Is(14)2Rdf Mutation: 3 strains or lines available

References

• Original: J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
• All: 2 reference(s)