Nr4a2^tm1.1Pcn
Targeted Allele Detail

Summary

• Symbol: Nr4a2^tm1.1Pcn
• Name: nuclear receptor subfamily 4, group A, member 2; targeted mutation 1.1, Pierre Chambon
• MGI ID: MGI:4437024
• Synonyms: Nr4a2^tm2.1Tpe, Nurr1^L2
• Gene: Nr4a2 Location: Chr2:56996842-57014015 bp, - strand Genetic Position: Chr2, 31.66 cM
• Alliance: Nr4a2^tm1.1Pcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157098
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removed the neo cassette leaving exon 3 floxed. (J:157098)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr4a2 Mutation: 44 strains or lines available

References

• Original: J:157098 Kadkhodaei B, et al., Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci. 2009 Dec 16;29(50):15923-32
• All: 17 reference(s)