Del(14Trim13-Dleu2)4Rdf
Targeted Allele Detail

Summary

• Symbol: Del(14Trim13-Dleu2)4Rdf
• Name: deletion, Chr 14, Riccardo Dalla-Favera 4
• MGI ID: MGI:4437040
• Synonyms: MDR^-
• Gene: Del(14Trim13-Dleu2)4Rdf Location: Chr14:61835696-61919822 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(14Trim13-Dleu2)4Rdf involves 13 genes/genome features (Gm27747, Gm27928, Gm27845 ...) View all
• Mutation details: The frt-flanked region between Is(14)1Rdf and Is(14)2Rdf and the GFP reporter were removed by Flp mediated recombination. Portions of Trim13, Kcnrg, Mir15a, Mir16-1, and Dleu2 are deleted. (J:156946)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(14Trim13-Dleu2)4Rdf Mutation: 0 strains or lines available

References

• Original: J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
• All: 4 reference(s)