Mirc30^tm1.2Rdf
Targeted Allele Detail

Summary

• Symbol: Mirc30^tm1.2Rdf
• Name: microRNA cluster 30, including Mir16-1 through Mir15a; targeted mutation 1.2, Riccardo Dalla-Favera
• MGI ID: MGI:4437041
• Gene: Mirc30 Location: Chr14:61869329-61869559 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was floxed and an FRT flanked neo cassette was inserted centromeric to the locus by homologous recombination. The selection cassette was removed by flp mediated recombination and the locus removed by cre mediated recombination. (J:156946)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc30 Mutation: 4 strains or lines available

References

• Original: J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
• All: 8 reference(s)