Mirc30^tm1.1Rdf
Targeted Allele Detail

Summary

• Symbol: Mirc30^tm1.1Rdf
• Name: microRNA cluster 30, including Mir16-1 through Mir15a; targeted mutation 1.1, Riccardo Dalla-Favera
• MGI ID: MGI:4437043
• Gene: Mirc30 Location: Chr14:61869329-61869559 bp Genetic Position: Chr14, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156946
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The locus was floxed and an FRT flanked neo cassette was inserted centromeric to the locus by homologous recombination. The selection cassette was removed by flp mediated recombination. RT-PCR confirmed normal expression of the micro RNAs and Dleu2. (J:156946)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mirc30^tm1.1Rdf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc30 Mutation: 4 strains or lines available

References

• Original: J:156946 Klein U, et al., The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010 Jan 19;17(1):28-40
• All: 15 reference(s)