Kcnu1^tm1Cmsa
Targeted Allele Detail

Summary

• Symbol: Kcnu1^tm1Cmsa
• Name: potassium channel, subfamily U, member 1; targeted mutation 1, Celia M Santi
• MGI ID: MGI:4437059
• Synonyms: SLO3-
• Gene: Kcnu1 Location: Chr8:26339651-26427967 bp, + strand Genetic Position: Chr8, 14.17 cM, cytoband A3
• Alliance: Kcnu1^tm1Cmsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutation was generated by removal of the first two coding exons which includes the initiation codon and DNA sequence encoding the first and part of the second membrane spanning domains. The absence of the protein expression was confirmed by Western blot analysis of testes samples. (J:157522)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnu1 Mutation: 63 strains or lines available

References

• Original: J:157522 Santi CM, et al., The SLO3 sperm-specific potassium channel plays a vital role in male fertility. FEBS Lett. 2010 Mar 5;584(5):1041-6
• All: 4 reference(s)