Lgi1^tm1Mafu
Targeted Allele Detail

Summary

• Symbol: Lgi1^tm1Mafu
• Name: leucine-rich repeat LGI family, member 1; targeted mutation 1, Masaki Fukata
• MGI ID: MGI:4437105
• Gene: Lgi1 Location: Chr19:38253135-38297387 bp, + strand Genetic Position: Chr19, 32.9 cM
• Alliance: Lgi1^tm1Mafu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157578
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:157578)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgi1 Mutation: 33 strains or lines available

References

• Original: J:157578 Fukata Y, et al., Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3799-3804
• All: 8 reference(s)