Maged1^tm1.1Urfm
Targeted Allele Detail

Summary

• Symbol: Maged1^tm1.1Urfm
• Name: MAGE family member D1; targeted mutation 1.1, Olivier De Backer
• MGI ID: MGI:4437118
• Gene: Maged1 Location: ChrX:93579080-93585631 bp, - strand Genetic Position: ChrX, 41.56 cM
• Alliance: Maged1^tm1.1Urfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157604
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-12 were floxed, and a floxed neo cassette was placed within intron 3 by homologous recombination. The neo cassette and floxed exons have been removed. Immunoblotting of brain lysates demonstrated that full-length protein was absent in homozygous animals. (J:157604)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Maged1 Mutation: 10 strains or lines available

References

• Original: J:157604 Bertrand MJ, et al., NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo. Cell Death Differ. 2008 Dec;15(12):1921-9
• All: 6 reference(s)