Pkd1^tm1Gztn
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1Gztn
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Thomas Natoli
• MGI ID: MGI:4437121
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1Gztn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162080
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 21 through 23 are flanked by loxP sites. (J:162080)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

Notes

ES Cell Line = AMK.

References

• Original: J:162080 Natoli TA, et al., Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med. 2010 Jul;16(7):788-92
• All: 1 reference(s)