Adam24^tm1Pmkf
Targeted Allele Detail

Summary

• Symbol: Adam24^tm1Pmkf
• Name: ADAM metallopeptidase domain 24; targeted mutation 1, Paul Primakoff
• MGI ID: MGI:4437125
• Gene: Adam24 Location: Chr8:41128118-41135238 bp, + strand Genetic Position: Chr8, 23.89 cM
• Alliance: Adam24^tm1Pmkf page

In vivo polyspermy with Adam24^tm1Pmkf/Adam24^tm1Pmkf male mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157046
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The first 576 amino acids have been eliminated by the insertion of a neomycin cassette by homologous recombination. The 88 KDa protein was absent on a western blot of mature sperm. (J:157046)

Generation of the Adam24^tm1Pmkf allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam24 Mutation: 31 strains or lines available

References

• Original: J:157046 Zhu GZ, et al., Testase 1 (ADAM 24) a sperm surface metalloprotease is required for normal fertility in mice. Mol Reprod Dev. 2009 Nov;76(11):1106-14
• All: 1 reference(s)