Nr1h2^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Nr1h2^tm1Dgen
• Name: nuclear receptor subfamily 1, group H, member 2; targeted mutation 1, Deltagen
• MGI ID: MGI:4437128
• Synonyms: Lxrbeta^-
• Gene: Nr1h2 Location: Chr7:44199040-44203375 bp, - strand Genetic Position: Chr7, 28.83 cM
• Alliance: Nr1h2^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157551
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129/Sv x C57BL/6)F1
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of the coding sequences for the gene. Mice were created from line T684. (J:157551)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h2 Mutation: 26 strains or lines available

References

• Original: J:157551 Li N, et al., LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3734-9
• All: 2 reference(s)