Setd2^tm1Zhch
Targeted Allele Detail

Summary

• Symbol: Setd2^tm1Zhch
• Name: SET domain containing 2; targeted mutation 1, Zhu Chen
• MGI ID: MGI:4437211
• Synonyms: Hypb^-
• Gene: Setd2 Location: Chr9:110361665-110447701 bp, + strand Genetic Position: Chr9, 60.0 cM
• Alliance: Setd2^tm1Zhch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157570
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence spanning most of exon 4 through part of exon 5 was replaced with a neo cassette disrupting the SET domain. (J:157570)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd2 Mutation: 102 strains or lines available

References

• Original: J:157570 Hu M, et al., Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
• All: 1 reference(s)