Chrm1^tm2.1Stl
Targeted Allele Detail

Summary

• Symbol: Chrm1^tm2.1Stl
• Name: cholinergic receptor, muscarinic 1, CNS; targeted mutation 2.1, Susumu Tonegawa
• MGI ID: MGI:4437231
• Gene: Chrm1 Location: Chr19:8641369-8660970 bp, + strand Genetic Position: Chr19, 5.44 cM
• Alliance: Chrm1^tm2.1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156540
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon 1 was flanked by loxP sites and an FRT flanked neo was inserted within intron 1 by homologous recombination. Flp mediated recombination removed the selection cassette. (J:156540)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm1 Mutation: 27 strains or lines available

References

• Original: J:156540 Kamsler A, et al., Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1618-23
• All: 10 reference(s)