Dhx58^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Dhx58^tm1Aki
• Name: DExH-box helicase 58; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4437255
• Gene: Dhx58 Location: Chr11:100585710-100595097 bp, - strand Genetic Position: Chr11, 63.52 cM
• Alliance: Dhx58^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5 were replaced by a neo cassette. Northern blot analysis failed to detect mRNA in homozygous MEFs. (J:156867)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dhx58 Mutation: 37 strains or lines available

References

• Original: J:156867 Satoh T, et al., LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
• All: 1 reference(s)