Dhx58^tm2.1Aki
Targeted Allele Detail

Summary

• Symbol: Dhx58^tm2.1Aki
• Name: DExH-box helicase 58; targeted mutation 2.1, Shizuo Akira
• MGI ID: MGI:4437256
• Synonyms: Dhx58^tm1(A30K)Aki, LGP2A30K/A30K, Lgp2^K30A
• Gene: Dhx58 Location: Chr11:100585710-100595097 bp, - strand Genetic Position: Chr11, 63.52 cM
• Alliance: Dhx58^tm2.1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Single point mutation
• Mutation details: A Lysine to Alanine change at reside 30 was created by a single point mutation within exon 1. A floxed neo selection cassette inserted within intron 3 has been removed by cre mediated recombination. (J:156867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dhx58 Mutation: 37 strains or lines available

References

• Original: J:156867 Satoh T, et al., LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1512-7
• All: 2 reference(s)