Nfatc2ip^tm1.1Glm
Targeted Allele Detail

Summary

• Symbol: Nfatc2ip^tm1.1Glm
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein; targeted mutation 1.1, Laurie Glimcher
• MGI ID: MGI:4437260
• Synonyms: Nip45^-
• Gene: Nfatc2ip Location: Chr7:125982026-125995909 bp, - strand Genetic Position: Chr7, 69.01 cM, cytoband F4
• Alliance: Nfatc2ip^tm1.1Glm page

Decrease in mast cells in the jejunum of T. spiralis-infected Nfatc2ip^tm1.1Glm/Nfatc2ip^tm1.1Glm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157559
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 1 and 2 were deleted and replaced with a floxed neomycin cassette. The selection cassette was removed by cre mediated recombination. RNA and protein absence were confirmed by northern and western blotting, respectively. Absence of expression did not alter the stability of its binding partners, NFATC1, NFATC2, and NFATC3 (J:157559)

Generation of the Nfatc2ip^tm1.1Glm allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc2ip Mutation: 129 strains or lines available

References

• Original: J:157559 Fathman JW, et al., NIP45 controls the magnitude of the type 2 T helper cell response. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3663-8
• All: 3 reference(s)