Ptk2tm1Heen
Targeted Allele Detail
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Symbol: |
Ptk2tm1Heen |
Name: |
PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen |
MGI ID: |
MGI:4437305 |
Synonyms: |
FAKdelta |
Gene: |
Ptk2 Location: Chr15:73076951-73295129 bp, - strand Genetic Position: Chr15, 33.94 cM
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Alliance: |
Ptk2tm1Heen page
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Hemorrhages, edemas, abnormal heart, lung, liver and limb development, and delayed artery formation and vascular remodeling defects in Ptk2tm1Heen/Ptk2tm1Heen embryos
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:157804
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The targeting vector replaced alternative exons 13 and 14 with an frt flanked hygro cassette and floxed the alternative exon 16. A spontaneous deletion of 307 bp removed exon 15. This deletion is expected to produce a protein lacking the autophosphorylation site tyrosine 397. Production of a truncated protein was confirmed by western blot analysis.
(J:157804)
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Generation of the Ptk2tm1Heen allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptk2 Mutation: |
91 strains or lines available
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Original: |
J:157804 Corsi JM, et al., Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76 |
All: |
1 reference(s) |
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