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Ptk2tm1Heen
Targeted Allele Detail
Summary
Symbol: Ptk2tm1Heen
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen
MGI ID: MGI:4437305
Synonyms: FAKdelta
Gene: Ptk2  Location: Chr15:73076951-73295129 bp, - strand  Genetic Position: Chr15, 33.94 cM
Alliance: Ptk2tm1Heen page
Hemorrhages, edemas, abnormal heart, lung, liver and limb development, and delayed artery formation and vascular remodeling defects in Ptk2tm1Heen/Ptk2tm1Heen embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:157804
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector replaced alternative exons 13 and 14 with an frt flanked hygro cassette and floxed the alternative exon 16. A spontaneous deletion of 307 bp removed exon 15. This deletion is expected to produce a protein lacking the autophosphorylation site tyrosine 397. Production of a truncated protein was confirmed by western blot analysis. (J:157804)
Generation of the Ptk2tm1Heen allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 44 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  91 strains or lines available
References
Original:  J:157804 Corsi JM, et al., Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development. J Biol Chem. 2009 Dec 11;284(50):34769-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory