Trdn^tm1.2Isma
Targeted Allele Detail

Summary

• Symbol: Trdn^tm1.2Isma
• Name: triadin; targeted mutation 1.2, Isabelle Marty
• MGI ID: MGI:4437311
• Gene: Trdn Location: Chr10:32959479-33352705 bp, + strand Genetic Position: Chr10, 18.37 cM, cytoband B1
• Alliance: Trdn^tm1.2Isma page

Abnormal skeletal muscle fiber triad morphology in Trdn^tm1.2Isma/Trdn^tm1.2Isma mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated recombination removed exon 1. The absence of all protein isoforms was confirmed by western blot analysis on muscle and heart extracts. (J:157794)

Generation of the Trdn^tm1.1Isma and Trdn^tm1.2Isma alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trdn Mutation: 59 strains or lines available

References

• Original: J:157794 Oddoux S, et al., Triadin deletion induces impaired skeletal muscle function. J Biol Chem. 2009 Dec 11;284(50):34918-29
• All: 5 reference(s)