Ptprt^tm1Sata
Targeted Allele Detail

Summary

• Symbol: Ptprt^tm1Sata
• Name: protein tyrosine phosphatase receptor type T; targeted mutation 1, Masanobu Satake
• MGI ID: MGI:4437410
• Synonyms: PTPRT^-, Ptprt^tm1Zhw
• Gene: Ptprt Location: Chr2:161363910-162503067 bp, - strand Genetic Position: Chr2, 81.91 cM
• Alliance: Ptprt^tm1Sata page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157542
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 22, containing the phosphatase catalytic core motif of the first catalytic domain, was replaced with a PGK-NeobpA cassette. (J:157542)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprt Mutation: 87 strains or lines available

References

• Original: J:157542 Zhao Y, et al., Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T. Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2592-7
• All: 3 reference(s)