Tg(Lrrk2*G2019S)2Yue
Transgene Detail
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Symbol: |
Tg(Lrrk2*G2019S)2Yue |
Name: |
transgene insertion 2, Zhenyu Yue |
MGI ID: |
MGI:4437428 |
Synonyms: |
FLAG-LRRK2-G2019S, LRRK2-G2019SOE |
Transgene: |
Tg(Lrrk2*G2019S)2Yue Location: Chr18:45101152-45101153 bp Genetic Position: Chr18, Syntenic
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Alliance: |
Tg(Lrrk2*G2019S)2Yue page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Lrrk2*G2019S)2Yue expresses
1 gene
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Mutation details: A bacterial artificial chromosome (BAC) (#RP23-312I9) containing the entire mouse Lrrk2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the Lrrk2 locus to harbor the Lrrk2-G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. This modified 240 kb BAC contains a FLAG-tag downstream from the start codon. Line 2 was established with expression in cerebral cortex, striatum, substantia nigra, internal capsule, and hippocampus at an approximately 6-8 fold greater level than endogenous mouse Lrrk2.
(J:128036)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:128036 Li X, et al., Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem. 2007 Oct;103(1):238-47 |
All: |
21 reference(s) |
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