Mid1^tm1Mero
Targeted Allele Detail

Summary

• Symbol: Mid1^tm1Mero
• Name: midline 1; targeted mutation 1, Germana Meroni
• MGI ID: MGI:4437430
• Gene: Mid1 Location: ChrX:168468178-168773692 bp, + strand Genetic Position: ChrXY, 79.19 cM
• Alliance: Mid1^tm1Mero page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157828
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment of the first coding exon including the first ATG was replaced with a neo selection cassette. RT-PCR and immunoblot analysis show the complete absence of the transcript and protein in embryos and adult brains, respectively. (J:157828)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mid1 Mutation: 195 strains or lines available

References

• Original: J:157828 Lancioni A, et al., Lack of Mid1, the mouse ortholog of the Opitz syndrome gene, causes abnormal development of the anterior cerebellar vermis. J Neurosci. 2010 Feb 24;30(8):2880-7
• All: 1 reference(s)