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Tg(Myh6*/tetO-Capn1)L3Gwd
Transgene Detail
Summary
Symbol: Tg(Myh6*/tetO-Capn1)L3Gwd
Name: transgene insertion L3, Gerald W Dorn II
MGI ID: MGI:4437470
Transgene: Tg(Myh6*/tetO-Capn1)L3Gwd  Location: unknown  
Alliance: Tg(Myh6*/tetO-Capn1)L3Gwd page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Mutation detailsThese MHCminTetO-Capn1 transgenic mice were generated by inserting the entire coding region of the mouse Calpain 1 gene into an MHCminTetO-promoter construct. The expression of this construct was driven by a mouse alpha-myosin heavy chain (alpha-MHC; Myh6) promoter under control of a tetracycline operator (tetO), followed by a human growth hormone polyadenylation (polyA) signal. This construct also contained 3 altered GATA sites and 2 altered thyroid-like response elements (TRE) maintaining low levels of cardiac-specific expression and decreased background. Three lines were created (L1, L2, and L3) with ascending levels of expression. (J:133797)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:133797 Galvez AS, et al., Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Circ Res. 2007 Apr 13;100(7):1071-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory