Ush1c^tm1Xzl
Targeted Allele Detail

Summary

• Symbol: Ush1c^tm1Xzl
• Name: USH1 protein network component harmonin; targeted mutation 1, Xue Liu
• MGI ID: MGI:4437562
• Gene: Ush1c Location: Chr7:45844774-45887927 bp, - strand Genetic Position: Chr7, 29.66 cM, cytoband B3
• Alliance: Ush1c^tm1Xzl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158047
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first four exons were replaced with a Beta galactosidase reporter and neomycin resistance genes, successfully eliminating expression of all of the many transcripts produced by this gene, including a, b, and c isoforms. (J:158047)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ush1c Mutation: 50 strains or lines available

References

• Original: J:158047 Tian C, et al., Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse. Brain Res. 2010 Apr 30;1328:57-70
• All: 6 reference(s)