Hapln2^tm1Ooh
Targeted Allele Detail

Summary

• Symbol: Hapln2^tm1Ooh
• Name: hyaluronan and proteoglycan link protein 2; targeted mutation 1, Toshitaka Oohashi
• MGI ID: MGI:4437572
• Synonyms: Bral1^-
• Gene: Hapln2 Location: Chr3:87929057-87934890 bp, - strand Genetic Position: Chr3, 38.78 cM, cytoband F1
• Alliance: Hapln2^tm1Ooh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157824
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ neo cassette was inserted within exon 4 by homologous recombination. Northern blot analysis of polyA+ RNA isolated from the brain showed absence of transcript. Western blotting demonstrated the complete absence of the full length protein. (J:157824)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hapln2 Mutation: 19 strains or lines available

References

• Original: J:157824 Bekku Y, et al., Bral1: its role in diffusion barrier formation and conduction velocity in the CNS. J Neurosci. 2010 Feb 24;30(8):3113-23
• All: 2 reference(s)