Elavl1^tm1.1Dkon
Targeted Allele Detail

Summary

• Symbol: Elavl1^tm1.1Dkon
• Name: ELAV like RNA binding protein 1; targeted mutation 1, Dimitris L Kontoyiannis
• MGI ID: MGI:4437584
• Synonyms: Elavl1^fl
• Gene: Elavl1 Location: Chr8:4335382-4375413 bp, - strand Genetic Position: Chr8, 2.0 cM
• Alliance: Elavl1^tm1.1Dkon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184388
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin cassette was placed upstream of the ATG-containing second exon with a third loxP site placed downstream of the exon. Cre mediated recombination removed the floxed neo cassette leaving the exon floxed. (J:149149, J:184388)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elavl1 Mutation: 43 strains or lines available

References

• Original: J:184388 Yiakouvaki A, et al., Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest. 2012 Jan 3;122(1):48-61
• All: 6 reference(s)