Nr1h4^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Nr1h4^tm1.2Auw
• Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:4437614
• Synonyms: Fxr^-
• Gene: Nr1h4 Location: Chr10:89290096-89369447 bp, - strand Genetic Position: Chr10, 44.98 cM
• Alliance: Nr1h4^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157882
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 6 was removed by cre mediated recombination from Nr1h4^tm1.1Auw. (J:157882)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr1h4 Mutation: 43 strains or lines available

References

• Original: J:157882 Milona A, et al., The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J Physiol Gastrointest Liver Physiol. 2010 Feb;298(2):G151-8
• All: 6 reference(s)