Arhgef5^tm1.1Dwu
Targeted Allele Detail

Summary

• Symbol: Arhgef5^tm1.1Dwu
• Name: Rho guanine nucleotide exchange factor 5; targeted mutation 1.1, Dianqing Wu
• MGI ID: MGI:4437666
• Synonyms: G5^-
• Gene: Arhgef5 Location: Chr6:43242578-43266250 bp, + strand Genetic Position: Chr6, 21.15 cM
• Alliance: Arhgef5^tm1.1Dwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157812
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre recombination removed exons 5 through 9. The absence of transcrpt expression was confirmed by RT-PCR on bone marrow cell extracts. (J:157812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef5 Mutation: 72 strains or lines available

References

• Original: J:157812 Wang Z, et al., Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem. 2009 Oct 16;284(42):28599-606
• All: 1 reference(s)