Fbn2^mz
Chemically induced Allele Detail

Summary

• Symbol: Fbn2^mz
• Name: fibrillin 2; mariusz
• MGI ID: MGI:4438056
• Gene: Fbn2 Location: Chr18:58141689-58343200 bp, - strand Genetic Position: Chr18, 32.15 cM, cytoband D-E1
• Alliance: Fbn2^mz page

Muscle weakness in Fbn2^mz/Fbn2^mz mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: BALB/cAnNCrl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T/A to A/T transversion in exon 14. This mutation replaced a leucine codon with a stop codon creating a truncation to 620 amino acids from 2907. (J:157998)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn2 Mutation: 143 strains or lines available

References

• Original: J:157998 Miller G, et al., ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2. PLoS One. 2010;5(2):e9137
• All: 1 reference(s)