Stat3^tm4Vpo
Targeted Allele Detail

Summary

• Symbol: Stat3^tm4Vpo
• Name: signal transducer and activator of transcription 3; targeted mutation 4, Valeria Poli
• MGI ID: MGI:4438059
• Synonyms: Stat3^C
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm4Vpo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157976
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: cDNA encoding the C-terminal portion of the gene with A661C and N663C mutations, as well as a polyA-neo cassette, was inserted into exon 20. The mutant protein was constitutively active and expressed at physiologic levels in mammary gland, liver and heart in both the homozygous and heterozygous mutant mice. (J:157976)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 72 strains or lines available

References

• Original: J:157976 Barbieri I, et al., Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten. Cancer Res. 2010 Mar 15;70(6):2558-67
• All: 3 reference(s)