Tg(ACTB-APP*V717F)1Colm
Transgene Detail

Summary

• Symbol: Tg(ACTB-APP*V717F)1Colm
• Name: transgene insertion 1, Colin L Masters
• MGI ID: MGI:4438112
• Synonyms: APPC100.V717F, Tg C100.V717F, TgC100.V717F
• Transgene: Tg(ACTB-APP*V717F)1Colm Location: unknown
• Alliance: Tg(ACTB-APP*V717F)1Colm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-APP*V717F)1Colm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes the London mutation.

• Mutation details: The human promoter was used to drive ubiquitous expression of the C-terminal portion of human APP (C100) with an amino acid substitution of phenyalanine for valine at position 717 (V717F), also known as the London mutation. One line was created (no line number given) with 40 to 50 copies of the transgene. (J:55025)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55025 Li QX, et al., Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. J Neurochem. 1999 Jun;72(6):2479-87
• All: 3 reference(s)