Tg(ACTB-APP)1Colm
Transgene Detail

Summary

• Symbol: Tg(ACTB-APP)1Colm
• Name: transgene insertion 1, Colin L Masters
• MGI ID: MGI:4438113
• Synonyms: TgC100, Tg C100.WT, TgC100.WT
• Transgene: Tg(ACTB-APP)1Colm Location: unknown
• Alliance: Tg(ACTB-APP)1Colm page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-APP)1Colm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The human promoter was used to drive ubiquitous expression of the wild-type C-terminal portion of human APP (C100). One line was created (no line number given) with 11 copies of the transgene. (J:55025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:55025 Li QX, et al., Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice. J Neurochem. 1999 Jun;72(6):2479-87
• All: 3 reference(s)