Phox2a^tm2.1Jbr
Targeted Allele Detail

Summary

• Symbol: Phox2a^tm2.1Jbr
• Name: paired-like homeobox 2a; targeted mutation 2.1, Jean-Francois Brunet
• MGI ID: MGI:4438118
• Synonyms: Phox2a^tm2Jbr
• Gene: Phox2a Location: Chr7:101467520-101471933 bp, + strand Genetic Position: Chr7, 54.66 cM
• Alliance: Phox2a^tm2.1Jbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157532
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and a FRT flanked neo marker was inserted in intron 2 by homologous recombination. The selection cassette was deleted by Flpe recombinase. (J:157532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phox2a Mutation: 10 strains or lines available

References

• Original: J:157532 Coppola E, et al., Epibranchial ganglia orchestrate the development of the cranial neurogenic crest. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2066-71
• All: 3 reference(s)