Tg(Cck-cre)CKres
Transgene Detail

Summary

• Symbol: Tg(Cck-cre)CKres
• Name: transgene insertion C, Kerry J Ressler
• MGI ID: MGI:4438218
• Synonyms: CCID, CCK-Cre, CCK-Cre-IRES-DsRed2
• Transgene: Tg(Cck-cre)CKres Location: unknown
• Alliance: Tg(Cck-cre)CKres page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Cck-cre)CKres expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Cck

• Mutation details: The coding sequence for cre recombinase, followed by an IRES and the DsRed2 sequence was placed downstream of a 3kb cholecystokinin (CCK) promoter. The construct was linearized, purified, and microinjected into the pronuclei of one-cell C57BL/6 embryos. Lines A, B, and C were established and analyzed. None of the three lines showed any observable DsRed fluorescence. Line C showed high levels of cre expression in the cortex, in a manner qualitatively similar to observed patterns of endogenous Cck mRNA expression, but showed almost no cre-mediated LacZ expression in any subcortical regions. (J:154361)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cck (species not specified) Summary of all recombinase alleles driven by Cck. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:154361 Chhatwal JP, et al., Identification of cell-type-specific promoters within the brain using lentiviral vectors. Gene Ther. 2007 Apr;14(7):575-83
• All: 5 reference(s)