Tg(Sprr2f-cre)1Dcas
Transgene Detail

Summary

• Symbol: Tg(Sprr2f-cre)1Dcas
• Name: transgene insertion 1, Diego H Castrillon
• MGI ID: MGI:4438222
• Synonyms: BAC-Sprr2f-Cre, Sprr2f-Cre
• Transgene: Tg(Sprr2f-cre)1Dcas Location: unknown
• Alliance: Tg(Sprr2f-cre)1Dcas page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Sprr2f-cre)1Dcas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Sprr2f

• Mutation details: A BAC derived 5.5 kb fragment of the Sprr2f promoter was cloned into a vector containing a cre coding sequence. Cre is expressed exclusively in endometrial epithelial cells and is naturally estrogen inducible due to the estrogen response elements in the Sprr2f regulatory region. The linearized construct was linearized and microinjected into FVB oocytes. Line 1 was assigned to this transgene in absence of specific line information. This transgene used different constructs compared to Tg(Sprr2f-cre)2Dcas generated by the same creator. (J:158190)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sprr2f (species not specified) Summary of all recombinase alleles driven by Sprr2f. Comparative matrix view of recombinase activities

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Sprr2f-cre)1Dcas

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:158190 Contreras CM, et al., Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010 Mar-Apr;3(3-4):181-93
• All: 14 reference(s)