Dkkl1^tm1.1Mldp
Targeted Allele Detail

Summary

• Symbol: Dkkl1^tm1.1Mldp
• Name: dickkopf-like 1; targeted mutation 1.1, Melvin DePamphilis
• MGI ID: MGI:4438465
• Gene: Dkkl1 Location: Chr7:44856943-44861571 bp, - strand Genetic Position: Chr7, 29.19 cM
• Alliance: Dkkl1^tm1.1Mldp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158272
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exons 2-4 of the Dickkopf-Like 1 (Dkkl1) gene, and a frt-flanked neomycin resistance (neo) cassette upstream of the 3' loxP site. Cre mediated recombination removed exons 2 through 4 and the frt-flanked neo cassette. The absence of protein expression was confirmed by immunohistochemistry on testis samples. (J:158272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dkkl1 Mutation: 13 strains or lines available

References

• Original: J:158272 Kaneko KJ, et al., The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility. Fertil Steril. 2010 Mar 15;93(5):1526-32
• All: 2 reference(s)