Inka1^tm1Will
Targeted Allele Detail

Summary

• Symbol: Inka1^tm1Will
• Name: inka box actin regulator 1; targeted mutation 1, Trevor Williams
• MGI ID: MGI:4438483
• Gene: Inka1 Location: Chr9:107861422-107863078 bp, - strand Genetic Position: Chr9, 59.07 cM, cytoband F2
• Alliance: Inka1^tm1Will page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157985
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 2 encoding approximately 185 amino acids, encompassing both the Inka1-box and 14-3-3 binding domain, was deleted and replaced with an IRES-LacZ reporter construct by homologous recombination. (J:157985)

Expression

In Mice Carrying this Mutation:	78 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inka1 Mutation: 11 strains or lines available

References

• Original: J:157985 Reid BS, et al., Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure. Dev Dyn. 2010 Feb 19;239(4):1188-1196
• All: 1 reference(s)