Tg(Myl1-cre)1Sjl
Transgene Detail

Summary

• Symbol: Tg(Myl1-cre)1Sjl
• Name: transgene insertion 1, Sejin Lee
• MGI ID: MGI:4438603
• Synonyms: MLC-Cre
• Transgene: Tg(Myl1-cre)1Sjl Location: unknown
• Alliance: Tg(Myl1-cre)1Sjl page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Myl1-cre)1Sjl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Myl1 (56781)

  Myl1	(MGI:97269)

• Mutation details: From 5' to 3' the tansgene contains a synthetic polyadenylation site, the rat myosin light chain 1 gene promoter, the cre recombinase gene modified to contain a Kozak consensus site immediately upstream of the start codon, intron and polyadenylation sites from the SV40 t antigen gene, and the rat myosin light chain 1/3 enhancer. A line was chosen that exhibited skeletal muscle-specific expression as determined by Northern analysis. (J:158173)

Schematic of the Tg(Myl1-cre)1Sjl transgene

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myl1 (rat) Summary of all recombinase alleles driven by Myl1. Alliance rat Myl1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158173 McPherron AC, et al., Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev Biol. 2009;9:24
• All: 3 reference(s)