Tg(Acvrl1-cre)B1Spo
Transgene Detail

Summary

• Symbol: Tg(Acvrl1-cre)B1Spo
• Name: transgene insertion B1, S Paul Oh
• MGI ID: MGI:4438606
• Synonyms: B1cre, Tg(Alk1-cre)-B1
• Transgene: Tg(Acvrl1-cre)B1Spo Location: unknown
• Alliance: Tg(Acvrl1-cre)B1Spo page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Acvrl1-cre)B1Spo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Acvrl1

• Mutation details: A construct composed of the 9.2 kb Alk1 regulatory fragment (containing a 2.7 kb promoter region and exon1-3 of Alk1), the SV40 splicing donor and acceptor (SD/SA), an internal ribosome-entry site (IRES), a polyadnylation signal and the cre recombinase sequence was used to generate the B1 transgenic cre line, as well as three other founder lines including the L1- and D-lines. B and D lines showed similar staining patterns when crossed to lacZ reporter animals. (J:130020)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acvrl1 (species not specified) Summary of all recombinase alleles driven by Acvrl1. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158116 Hong KH, et al., Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension. Circulation. 2008 Aug 12;118(7):722-30
• All: 2 reference(s)