Pkdcc^tm1.1Mask
Targeted Allele Detail

Summary

• Symbol: Pkdcc^tm1.1Mask
• Name: protein kinase domain containing, cytoplasmic; targeted mutation 1.1, Masaki Kinoshita
• MGI ID: MGI:4438609
• Synonyms: Vlk^-
• Gene: Pkdcc Location: Chr17:83522721-83532499 bp, + strand Genetic Position: Chr17, 52.25 cM
• Alliance: Pkdcc^tm1.1Mask page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158147
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with an attB1 site, Venus gene, floxed neo cassette, and attB2 site. Cre mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by RT-PCR on E12.5 whole embryo extracts. (J:158147)

Expression

In Mice Carrying this Mutation:	45 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkdcc Mutation: 24 strains or lines available

References

• Original: J:158147 Kinoshita M, et al., The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development. 2009 Jun;136(12):2069-79
• All: 2 reference(s)