Dbn1^tm1.1Shira
Targeted Allele Detail

Summary

• Symbol: Dbn1^tm1.1Shira
• Name: drebrin 1; targeted mutation 1.1, Tomoaki Shirao
• MGI ID: MGI:4438710
• Synonyms: DAKO
• Gene: Dbn1 Location: Chr13:55621241-55635874 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Dbn1^tm1.1Shira page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158208
• Parent Cell Line: MS12 (ES Cell)
• Strain of Origin: C57BL/6NSlc

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette was inserted within exon 11a and exon 11a was floxed by homologous recombination. The neo cassette and exon 11a were removed by cre mediated recombination. Western blotting confirmed the presence of the E form instead of the A form in cerebral cortices lysates of adult. (J:158208)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbn1 Mutation: 44 strains or lines available

References

• Original: J:158208 Kojima N, et al., Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neuroscience. 2010 Jan 13;165(1):138-50
• All: 6 reference(s)