Dagla^tm1Pado
Targeted Allele Detail

Summary

• Symbol: Dagla^tm1Pado
• Name: diacylglycerol lipase, alpha; targeted mutation 1, Patrick Doherty
• MGI ID: MGI:4438719
• Gene: Dagla Location: Chr19:10222629-10282241 bp, - strand Genetic Position: Chr19, 6.55 cM
• Alliance: Dagla^tm1Pado page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157850
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 was replaced by a GFP-Neo selection cassette by homologous recombination. Absence of RNA and protein was confirmed by quantitative RT-PCR and western blot analysis of cerebellum extracts. (J:157850)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dagla Mutation: 62 strains or lines available

References

• Original: J:157850 Gao Y, et al., Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci. 2010 Feb 10;30(6):2017-24
• All: 7 reference(s)