Kdm3a^tm1.1Jsak
Targeted Allele Detail

Summary

• Symbol: Kdm3a^tm1.1Jsak
• Name: lysine (K)-specific demethylase 3A; targeted mutation 1.1, Juro Sakai
• MGI ID: MGI:4438720
• Synonyms: JHDM2a^delta
• Gene: Kdm3a Location: Chr6:71565954-71609963 bp, - strand Genetic Position: Chr6, 32.18 cM
• Alliance: Kdm3a^tm1.1Jsak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158258
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed the cDNA corresponding to the genomic sequence of exon 20 through the coding region of exon 25 and a neo cassette. The absence of fully length protein expression was confirmed by western blot analysis on embryonic stem cell extracts. (J:158258)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm3a Mutation: 81 strains or lines available

References

• Original: J:158258 Inagaki T, et al., Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice. Genes Cells. 2009 Aug;14(8):991-1001
• All: 4 reference(s)