Tg(Thy1-APPDutch)#Jckr
Transgene Detail

Summary

• Symbol: Tg(Thy1-APPDutch)#Jckr
• Name: transgene insertion, Mathias Jucker
• MGI ID: MGI:4438890
• Transgene: Tg(Thy1-APPDutch)#Jckr Location: unknown
• Alliance: Tg(Thy1-APPDutch)#Jckr page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APPDutch)#Jckr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

  The gene encodes for the Dutch mutation.

• Mutation details: A human APP751 cDNA with a mutation in the codon for amino acid residue 693 causing a glutamic acid to glutamine change (E693Q) was place under the control of the murine Thy1.2 minigene. Five positive founder mice were identified. This record is for combined data from the two highest expressing lines, lines 23 and 33. Expression is five times higher than for endogenous APP. (J:92796)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:92796 Herzig MC, et al., Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004 Sep;7(9):954-60
• All: 8 reference(s)