Tg(Thy1-APP)16Ppa
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP)16Ppa
• Name: transgene insertion 16, Paolo Paganetti
• MGI ID: MGI:4438891
• Synonyms: APP51/22, Tg(Thy1-APP)51/16Npa
• Transgene: Tg(Thy1-APP)16Ppa Location: unknown
• Alliance: Tg(Thy1-APP)16Ppa page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP)16Ppa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: A human APP751 cDNA was placed under the control of the murine Thy-1 minigene. This particular transgenic line expresses human APP at a level five or more fold greater than expression of the endogenous gene. (J:75039)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:92796 Herzig MC, et al., Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis. Nat Neurosci. 2004 Sep;7(9):954-60
• All: 12 reference(s)