Adam10^tm1.1Dhc
Targeted Allele Detail

Summary

• Symbol: Adam10^tm1.1Dhc
• Name: a disintegrin and metallopeptidase domain 10; targeted mutation 1.1, Daniel H Conrad
• MGI ID: MGI:4438892
• Synonyms: AD10 fl, Adam10^delta
• Gene: Adam10 Location: Chr9:70586279-70687511 bp, + strand Genetic Position: Chr9, 39.53 cM
• Alliance: Adam10^tm1.1Dhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158127
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 9, which encodes the Zinc-binding domain of the protease active site, was flanked by loxP sites. The Neo cassette was removed from the germline by FLP mediated recombination. (J:158127)

Generation of the Adam10^tm1.1Dhc allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam10 Mutation: 38 strains or lines available

References

• Original: J:158127 Gibb DR, et al., ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010 Mar 15;207(3):623-35
• All: 12 reference(s)