Srr^tm1.2Jtc
Targeted Allele Detail

Summary

• Symbol: Srr^tm1.2Jtc
• Name: serine racemase; targeted mutation 1.2, Joseph T Coyle
• MGI ID: MGI:4438917
• Synonyms: SR^-
• Gene: Srr Location: Chr11:74797185-74816774 bp, - strand Genetic Position: Chr11, 45.76 cM, cytoband B4
• Alliance: Srr^tm1.2Jtc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158266
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin phosphotransferase cassette was inserted with intron 1 and another loxP sequence 5' to exon 1 by homologous recombination. The selection cassette and exon 1 were removed by cre mediated recombination. Absence of protein was confirmed by western blot of whole brain extracts. (J:158266)

Disease models

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srr Mutation: 32 strains or lines available

References

• Original: J:158266 Basu AC, et al., Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry. 2009 Jul;14(7):719-27
• All: 26 reference(s)