Creb3l2^tm1Kaim
Targeted Allele Detail

Summary

• Symbol: Creb3l2^tm1Kaim
• Name: cAMP responsive element binding protein 3-like 2; targeted mutation 1, Kazunori Imaizumi
• MGI ID: MGI:4438923
• Synonyms: Bbf2h7^-, Creb3l2^tm1Kami
• Gene: Creb3l2 Location: Chr6:37307956-37419083 bp, - strand Genetic Position: Chr6, 16.18 cM
• Alliance: Creb3l2^tm1Kaim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158241
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 was replaced with a STOP codon and neo cassette. The absence of protein expression was confirmed by western blot analysis on chondrocyte extracts. (J:158241)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Creb3l2 Mutation: 22 strains or lines available

References

• Original: J:158241 Saito A, et al., Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis. Nat Cell Biol. 2009 Oct;11(10):1197-204
• All: 4 reference(s)